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Anti-SRY Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG) -box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome) ; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.

Synonyms

Sex-determining region Y protein; Testis-determining factor; SRY; TDF

Gene Name

SRY

Gene ID

6736

UniProt

Q05066

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human SRY.

Clonality

Polyclonal

Tissue Specificity

Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. .

Applications

Flow Cytometry

Field of Research

Developmental Biology, Domain Families, Epigenetics and Nuclear Signaling, Histones, Reproduction, Transcription, Transcription Factors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by ing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity) . In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity) . Involved in different aspects of gene regulation including promoter activation or repression (By similarity) . Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. .

References & Citations

1. Biason-Lauber A, Konrad D, Meyer M, DeBeaufort C, Schoenle EJ (May 2009) . Ovaries and female phenotype in a girl with 46, XY karyotype and mutations in the CBX2 gene. Am. J. Hum. Genet. 84 (5) : 658–63. 2. Margarit E, Coll MD, Oliva R, Gómez D, Soler A, Ballesta F (January 2000) . SRY gene transferred to the long arm of the X chromosome in a Y-positive XX true hermaphrodite. Am. J. Med. Genet. 90 (1) : 25–8. 3. Polanco JC, Koopman P (February 2007) . Sry and the hesitant beginnings of male development. Dev. Biol. 302 (1) : 13–24.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

23884 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Sex-determining region Y protein

Subcellular Location

Nucleus speckle. Cytoplasm. Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus. Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity) . .

Protein Name

Growth arrest-specific protein 6

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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