Anti-Syndecan-1/SDC1 Antibody Picoband®

Syndecan 1 is a protein which in humans is encoded by the SDC1 gene. The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.

E. coli-derived human Syndecan-1/SDC1 recombinant protein (Position: Q23-G254) . Human Syndecan-1/SDC1 shares 69.2% and 69.8% amino acid (aa) sequence identity with mouse and rat Syndecan-1/SDC1, respectively.

Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology. .

Cancer, Cancer Metabolism, Cell Adhesion Proteins, Cell Type Marker, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Hematopoietic Progenitors, Invasion/Microenvironment, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lymphoid, Membrane Proteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Pathways and Processes, Signal Transduction, Stem Cells, Synapse Marker

1. Ala-Kapee M, Nevanlinna H, Mali M, Jalkanen M, Schröder J (September 1990) . Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2. Somat. Cell Mol. Genet.16 (5) : 501–5. 2. Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (April 1990) . Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans. J. Biol. Chem. 265 (12) : 6884–9.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.