Anti-NOV/CCN3 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
NOV (nephroblastoma overexpressed), also known as CCN3, is a matricellular protein that in humans is encoded by the NOV gene. The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development.
Synonyms
Protein NOV homolog; NovH; CCN family member 3; Insulin-like growth factor-binding protein 9; IBP-9; IGF-binding protein 9; IGFBP-9; Nephroblastoma-overexpressed gene protein homolog; NOV; CCN3, IGFBP9, NOVH
Gene Name
NOV
Gene ID
4856
UniProt
P48745
Host
Rabbit
Reactivity
Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human NOV/CCN3, different from the related mouse sequence by seven amino acids, and from the related rat sequence by four amino acids.
Clonality
Polyclonal
Tissue Specificity
Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type. .
Applications
Flow Cytometry
Field of Research
DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing
Purification
Immunogen affinity purified.
Form
Liquid
Function
Immediate-early protein likely to play a role in cell growth regulation. .
References & Citations
1. Jun JI, Lau LF (Dec 2011) . Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nature Reviews. Drug Discovery. 10 (12) : 945–63. 2. Martinerie C, Viegas-Pequignot E, Guenard I, Dutrillaux B, Nguyen VC, Bernheim A, Perbal B (Dec 1992) . Physical mapping of human loci homologous to the chicken nov proto-oncogene. Oncogene. 7 (12) : 2529–34.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39162 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Protein NOV homolog
Subcellular Location
Secreted.
Protein Name
AP-2 complex subunit mu
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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