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Anti-L17A Receptor/IL17RA Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene. The IL17R gene is mapped to 22q11.22-q11.23 by radiation hybrid analysis. Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.

Synonyms

Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; CDw217; CD217; IL17RA; IL17R

Gene Name

IL17RA

Gene ID

23765

UniProt

Q96F46

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human IL17RA recombinant protein (Position: K53-Q284) . Human IL17RA shares 74.1% amino acid (aa) sequence identity with mouse IL17RA.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. .

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for IL17A (PubMed:17911633, PubMed:9367539) . Receptor for IL17F (PubMed:19838198, PubMed:17911633) . Binds to IL17A with higher affinity than to IL17F (PubMed:17911633) . Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495) . Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971) . Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848) . Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971) . .

References & Citations

1. Entrez Gene: IL17RA interleukin 17 receptor A. 2. Yao, Z., Spriggs, M. K., Derry, J. M. J., Strockbine, L., Park, L. S., VandenBos, T., Zappone, J., Painter, S. L., Armitage, R. J. Molecular characterization of the human interleukin (IL) -17 receptor. Cytokine 9: 794-800, 1997. 3. Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A.-M., Painter, S. L., Comeau, M. R., Cohen, J. I., Spriggs, M. K. Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3: 811-821, 1995.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

96122 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin-17 receptor A

Subcellular Location

Isoform 1: Cell membrane ; Single-pass type I membrane protein .

Protein Name

Peptidyl-prolyl cis-trans isomerase A

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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