Anti-Hsp20/HSPB6 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Heat shock protein beta-6 is a protein that in humans is encoded by the HSPB6 gene. HSPB6, also known as hsp20, is a 17-kDa member of the small heat shock family of proteins. It is expressed in multiple tissues; however, HSPB6 is most highly and constitutively expressed in different types of muscle including vascular, airway, colonic, bladder, uterine smooth muscle, cardiac muscle and skeletal muscle. HSPB6 has specific functions for vasodilation, platelet function, and insulin resistance and in smooth and cardiac muscle.
Synonyms
Heat shock protein beta-6; HspB6; Heat shock 20 kDa-like protein p20; HSPB6
Gene Name
HSPB6
Gene ID
126393
UniProt
O14558
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Hsp20 recombinant protein (Position: H73-L123) . Human Hsp20 shares 88.2% and 92.2% amino acid (aa) sequence identity with mouse and rat Hsp20, respectively.
Clonality
Polyclonal
Tissue Specificity
Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas.
Applications
Flow Cytometry
Field of Research
Atherosclerosis, Cardiovascular, Chaperones, Heat Shock Proteins, Protein Trafficking, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.
References & Citations
1. Entrez Gene: HSPB6 heat shock protein, alpha-crystallin-related, B6. 2. Bukach OV, Seit-Nebi AS, Marston SB, Gusev NB (Jan 2004) . Some properties of human small heat shock protein Hsp20 (HspB6) . Eur J Biochem. 271 (2) : 291–302. 3. Dreiza CM, Komalavilas P, Furnish EJ, Flynn CR, Sheller MR, Smoke CC, Lopes LB, Brophy CM (Jan 2010) .The small heat shock protein, HSPB6, in muscle function and disease. Cell Stress Chaperones. 15 (1) : 1–11.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
17136 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Heat shock protein beta-6
Subcellular Location
Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock.
Protein Name
Chromaffin granule amine transporter
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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