Anti-HOXB1 Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.
Synonyms
Homeobox protein Hox-B1; Homeobox protein Hox-2I; HOXB1; HOX2I
Gene Name
HOXB1
Gene ID
3211
UniProt
P14653
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human HOXB1, different from the related mouse sequence by four amino acids.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
References & Citations
1. Iimura, T., Pourquie, O. Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression. Nature 442: 568-571, 2006. 2. Goddard, J. M., Rossel, M., Manley, N. R., Capecchi, M. R. Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development 122: 3217-3228, 1996. 3. Webb, B. D., Shaaban, S., Gaspar, H., Cunha, L. F., Schubert, C. R., Hao, K., Robson, C. D., Chan, W.-M., Andrews, C., MacKinnon, S., Oystreck, D. T., Hunter, D. G., Iacovelli, A. J., Ye, X., Camminady, A., Engle, E. C., Jabs, E. W. HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice. Am. J. Hum. Genet. 91: 171-179, 2012.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
32193 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Homeobox protein Hox-B1
Subcellular Location
Nucleus.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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