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Anti-HOXB1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.

Synonyms

Homeobox protein Hox-B1; Homeobox protein Hox-2I; HOXB1; HOX2I

Gene Name

HOXB1

Gene ID

3211

UniProt

P14653

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human HOXB1, different from the related mouse sequence by four amino acids.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Transcription

Purification

Immunogen affinity purified.

Form

Liquid

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

References & Citations

1. Iimura, T., Pourquie, O. Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression. Nature 442: 568-571, 2006. 2. Goddard, J. M., Rossel, M., Manley, N. R., Capecchi, M. R. Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development 122: 3217-3228, 1996. 3. Webb, B. D., Shaaban, S., Gaspar, H., Cunha, L. F., Schubert, C. R., Hao, K., Robson, C. D., Chan, W.-M., Andrews, C., MacKinnon, S., Oystreck, D. T., Hunter, D. G., Iacovelli, A. J., Ye, X., Camminady, A., Engle, E. C., Jabs, E. W. HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice. Am. J. Hum. Genet. 91: 171-179, 2012.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

32193 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Homeobox protein Hox-B1

Subcellular Location

Nucleus.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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