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Anti-FMN1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Formins, such as FMN1, are actin-nucleating proteins involved in cell polarity, cytokinesis, cell migration, and transcriptional activity. This FMN1 gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene.

Synonyms

Formin-1; Limb deformity protein homolog; FMN1; FMN, LD

Gene Name

FMN1

Gene ID

342184

UniProt

Q68DA7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human FMN1 recombinant protein (Position: N1195-N1419) . Human FMN1 shares 93.8% amino acid (aa) sequence identity with mouse FMN1.

Clonality

Polyclonal

Tissue Specificity

Expressed ubiquitously.

Applications

Flow Cytometry

Field of Research

Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Plays a role in the formation of adherens junction and the polymerization of linear actin cables. .

References & Citations

1. Chalkia D, Nikolaidis N, Makalowski W, Klein J, Nei M (December 2008) . Origins and evolution of the forminmultigene family that is involved in the formation of actin filaments. Molecular Biology and Evolution. 25 (12) : 2717–33. 2. Evangelista M, Zigmond S, Boone C (July 2003) . Formins: signaling effectors for assembly and polarization of actin filaments. Journal of Cell Science. 116 (Pt 13) : 2603–11. 3. Goode BL, Eck MJ (2007) . Mechanism and function of formins in the control of actin assembly. Annual Review of Biochemistry. 76: 593–627.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

157578 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Formin-1

Subcellular Location

Nucleus . Cytoplasm . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions and to microtubules (By similarity) . .

Protein Name

BAG family molecular chaperone regulator 5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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