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Anti-Epigen/Epgn Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene. The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate.

Synonyms

Epigen; Epithelial mitogen; EPG; Epgn

Gene Name

Epgn

Gene ID

71920

UniProt

Q924X1

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse Epigen recombinant protein (Position: A19-K109) . Mouse Epigen shares 82.8% amino acid (aa) sequence identity with human Epigen.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Cancer, Growth Factors, Growth Factors/Hormones, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

References & Citations

1. Entrez Gene: Epithelial mitogen. 2. Schneider MR, Yarden Y (2014) . Structure and function of epigen, the last EGFR ligand. Semin. Cell Dev. Biol. 28: 57–61.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

16799 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Epigen

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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