Anti-SAP102/DLG3 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene. DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation.

Synonyms

Disks large homolog 3; Neuroendocrine-DLG; Synapse-associated protein 102; SAP-102; SAP102; XLMR; DLG3; KIAA1232

Gene Name

DLG3

Gene ID

1741

UniProt

Q92796

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human SAP102 recombinant protein (Position: E749-L817) . Human SAP102 shares 98.6% amino acid (aa) sequence identity with both mouse and rat SAP102.

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.

Applications

Flow Cytometry

Field of Research

Adapters, Cell Type Marker, Intracellular Signaling, Neuron Marker, Neuroscience, Neurotransmission, Synapse Marker

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.

References & Citations

1. Stathakis DG, Lee D, Bryant PJ (Aug 1998) . DLG3, the gene encoding human neuroendocrine Dlg (NE-Dlg), is located within the 1.8-Mb dystonia-parkinsonism region at Xq13.1. Genomics. 49 (2) : 310–3. 2. Entrez Gene: DLG3 Discs, large homolog 3 (neuroendocrine-dlg, Drosophila) .

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

90 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Disks large homolog 3

Subcellular Location

Nucleus speckle. PML body. Nucleus.

Protein Name

Chromodomain-helicase-DNA-binding protein 2

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-SAP102/DLG3 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Protein Name

Isotype

Contents

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