Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-CTLA4 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein receptor that down regulates the immune system. It is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Blockade of CTLA4 expression in vitro augmented HIV-specific CD4-positive T-cell function.

Synonyms

Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; Ctla4; Cd152

Gene Name

Ctla4

Gene ID

12477

UniProt

P09793

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse CTLA4 recombinant protein (Position: E36-D161) . Mouse CTLA4 shares 67.5% amino acid (aa) sequence identity with human CTLA4.

Clonality

Polyclonal

Tissue Specificity

Widely expressed with highest levels in lymphoid tissues. .

Applications

Flow Cytometry

Field of Research

T Cells, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Form

Liquid

Function

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (By similarity) . .

References & Citations

1. Dariavach P, Mattéi MG, Golstein P, Lefranc MP (December 1988) . Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur. J. Immunol. 18 (12) : 1901–5. 2. Magistrelli G, Jeannin P, Herbault N, Benoit De Coignac A, Gauchat JF, Bonnefoy JY, Delneste Y (November 1999) . A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells.Eur. J. Immunol. 29 (11) : 3596–602. 3. Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW (November 1995) . Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270 (5238) : 985–8.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

24993 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Cytotoxic T-lymphocyte protein 4

Subcellular Location

Cell membrane ; Single-pass type I membrane protein .

Protein Name

Receptor tyrosine-protein kinase erbB-2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

Mouse Rnf10 activation kit by CRISPRa
GA205379 1 Kit

Mouse Rnf10 activation kit by CRISPRa

Sign In for Pricing
View Details
PerCP/Cyanine5.5 anti-mouse H-2Kb
GT02384 100 µg

PerCP/Cyanine5.5 anti-mouse H-2Kb

Sign In for Pricing
View Details
A330049M08Rik ORF Vector (Mouse) (pORF)
ORF037655 1.0 µg DNA

A330049M08Rik ORF Vector (Mouse) (pORF)

Sign In for Pricing
View Details
TEP1 discontinued
395257 200 µL

TEP1 discontinued

Sign In for Pricing
View Details
CFP protein, Human, Recombinant (His)
E51P80078 20 µg

CFP protein, Human, Recombinant (His)

Sign In for Pricing
View Details
Rabbit Polyclonal ADAT1 Antibody [DyLight 405]
NBP2-97762V 0.1 mL

Rabbit Polyclonal ADAT1 Antibody [DyLight 405]

Sign In for Pricing
View Details