Anti-Caspase-6/CASP6 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Caspase 6 is an enzyme that in humans is encoded by the CASP6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Using radiation hybrid mapping, the CASP6 gene is localized to human chromosome 4q25-q26. It functions as a downstream enzyme in the caspase activation cascade. And CASP6 can cleave lamin A to its signature apoptotic fragment.
Synonyms
Caspase-6; CASP-6;3.4.22.59; Apoptotic protease Mch-2; Caspase-6 subunit p18; Caspase-6 subunit p11; CASP6; MCH2
Gene Name
CASP6
Gene ID
839
UniProt
P55212
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Caspase-6 recombinant protein (Position: A194-N293) . Human Caspase-6 shares 95.9% and 93.9% amino acid (aa) sequence identity with mouse and rat Caspase-6, respectively.
Clonality
Polyclonal
Tissue Specificity
Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.
Applications
Flow Cytometry
Field of Research
Metabolism, Metabolism Processes, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways and Processes
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly (ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
References & Citations
1. Fernandes-Alnemri, T., Litwack, G., Alnemri, E. S.Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.Cancer Res. 55: 2737-2742, 1995. 2. Nikolaev, A., McLaughlin, T., O'Leary, D. D. M., Tessier-Lavigne, M.APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457: 981-989, 2009. 3. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., Dixit, V. M.The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.J. Biol. Chem. 271: 16443-16446, 1996.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
33310 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Caspase-6
Subcellular Location
Cytoplasm.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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