Anti-C19orf80/ANGPTL8 Antibody Picoband®

ANGPTL8 (also known as lipasin, originally Betatrophin) is a protein that in humans is encoded by the C19orf80 gene. The gene for betatrophin lies on mouse chromosome 9 (gene symbol: Gm6484) and on human chromosome 19 (gene symbol: C19orf80) . The encoded 22 kDa protein contains an N-terminal secretion signal and two coiled-coil domains and is a member of the angiopoietin-like (ANGPTL) protein family. However, in contrast to other ANGPTL proteins, betatrophin lacks the C-terminal fibrinogen-like domain, and therefore it is an atypical member of the ANGPTL family. It shares with Angptl4 and Angptl3 the ability to inhibit the enzyme Lipoprotein lipase (LPL), and its hepatic overexpression causes elevation of circulating Triglyceride levels in mice. In mice betatrophin is secreted by the liver. It was hoped that betatrophin or its homolog in humans may provide an effective treatment for type 2 diabetes and perhaps even type I diabetes.

E.coli-derived human C19orf80 recombinant protein (Position: A22-A198) . Human C19orf80 shares 74% amino acid (aa) sequence identity with mouse C19orf80.

Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577) . May be involved in the metabolic transition between fasting and refeeding: required to fatty acids to adipose tissue for storage in the fed state (By similarity) . .

1. Fu Z, Yao F, Abou-Samra AB, Zhang R (Jan 2013) . Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochemical and Biophysical Research Communications. 430 (3) : 1126–31. 2. Yi P, Park JS, Melton DA (May 2013) . Betatrophin: a hormone that controls pancreatic β cell proliferation. Cell. 153 (4) : 747–58. 3. Zhang R (Aug 2012) . Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochemical and Biophysical Research Communications. 424 (4) : 786–92.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.