Anti-MATH1/HATH1/ATOH1 Antibody Picoband® Fluoro647 Conjugated

Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene. This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. ATOH1 is required for the formation of both neural and non-neural cell types. Using genetic deletion in mice, Atoh1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells) .

A synthetic peptide corresponding to a sequence at the N-terminus of human MATH1/HATH1, different from the related mouse sequence by three amino acids.

Auditory System, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Neurogenesis, Neurology Process, Neuroscience, Nuclear, Sensory System, Signaling Pathways, Stem Cells, Transcription

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) . .

1. Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ, Zoghbi HY (Sep 1996) . Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. Human Molecular Genetics. 5 (9) : 1207–16. 2. Entrez Gene: ATOH1 atonal homolog 1 (Drosophila) .