Anti-MRP1/ABCC1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
Synonyms
Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Leukotriene C (4) transporter; LTC4 transporter; ABCC1; MRP, MRP1
Gene Name
ABCC1
Gene ID
4363
UniProt
P33527
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human MRP1, different from the related mouse sequence by five amino acids, and from the related rat sequence by four amino acids.
Clonality
Polyclonal
Tissue Specificity
Lung, testis and peripheral blood mononuclear cells.
Applications
Flow Cytometry
Field of Research
ATPases, Cancer, Channels, Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. .
References & Citations
1. Entrez Gene: ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1. 2. Rosenberg MF, Mao Q, Holzenburg A, Ford RC, Deeley RG, Cole SP (May 2001) . The structure of the multidrug resistance protein 1 (MRP1/ABCC1) . crystallization and single-particle analysis. The Journal of Biological Chemistry. 276 (19) : 16076–82. 3. Yin J, Zhang J (October 2011) . Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences. 36 (10) : 927–38.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
171591 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Multidrug resistance-associated protein 1
Subcellular Location
Cell membrane ; Multi-pass membrane protein .
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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