Anti-MRP1/ABCC1 Antibody Picoband® Fluoro594 Conjugated

Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.

Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Leukotriene C (4) transporter; LTC4 transporter; ABCC1; MRP, MRP1

A synthetic peptide corresponding to a sequence at the C-terminus of human MRP1, different from the related mouse sequence by five amino acids, and from the related rat sequence by four amino acids.

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. .

1. Entrez Gene: ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1. 2. Rosenberg MF, Mao Q, Holzenburg A, Ford RC, Deeley RG, Cole SP (May 2001) . The structure of the multidrug resistance protein 1 (MRP1/ABCC1) . crystallization and single-particle analysis. The Journal of Biological Chemistry. 276 (19) : 16076–82. 3. Yin J, Zhang J (October 2011) . Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences. 36 (10) : 927–38.