Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-NCKAP1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Nck-associated protein 1 is a protein that in humans is encoded by the NCKAP1 gene. By somatic cell hybrid analysis, the NCKAP1 gene was mapped to chromosome 2. NCKAP1 is a predicted type II transmembrane protein, with a C-terminal transmembrane domain. It was demonstrated that suppression of NCKAP1 expression using an antisense NCKAP1 oligonucleotide induced apoptosis of neuronal cells.

Synonyms

Nck-associated protein 1; NAP 1; Membrane-associated protein HEM-2; p125Nap1; NCKAP1; HEM2, KIAA0587, NAP1

Gene Name

NCKAP1

Gene ID

10787

UniProt

Q9Y2A7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human NCKAP1 recombinant protein (Position: S2-K201) . Human NCKAP1 shares 98.5% and 98% amino acid (aa) sequence identity with mouse and rat NCKAP1, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle.

Applications

Flow Cytometry

Field of Research

Neurogenesis, Neurology Process, Neuroscience, NFKB Pathway, Nuclear Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.

References & Citations

1. Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (Aug 2002) . Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature. 418 (6899) : 790–3. 2. Kitamura Y, Kitamura T, Sakaue H, Maeda T, Ueno H, Nishio S, Ohno S, Osada SI, Sakaue M, Ogawa W, Kasuga M (Mar 1997) . Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac. The Biochemical Journal. 322 (Pt 3) : 873–8. 3. Suzuki, T., Nishiyama, K., Yamamoto, A., Inazawa, J., Iwaki, T., Yamada, T., Kanazawa, I., Sakaki, Y. Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease. Genomics 63: 246-254, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

128790 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Nck-associated protein 1

Subcellular Location

Cell membrane ; Single-pass membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Single-pass membrane protein ; Cytoplasmic side . At the interface between the lamellipodial actin meshwork and the membrane. .

Protein Name

Nck-associated protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Tetracycline antibody
MBS839722-01 1 mg

Tetracycline antibody

Ask
View Details
Tetracycline antibody
MBS839722-02 5x 1 mg

Tetracycline antibody

Ask
View Details
OAS1 (2'-5'-Oligoadenylate Synthase 12'-5'-Oligoadenylate Synthetase 1, 40/46kD)
487446 100 µL

OAS1 (2'-5'-Oligoadenylate Synthase 12'-5'-Oligoadenylate Synthetase 1, 40/46kD)

Ask
View Details
RXRA Adenovirus (Human)
42914051 1.0 mL

RXRA Adenovirus (Human)

Ask
View Details
Anti-GGPS1 antibody
PAab03445 100 µg

Anti-GGPS1 antibody

Ask
View Details
DNA Polymerase delta Interacting Protein p38, CT (Polymerase delta-interacting Protein 2, 38kD DNA Polymerase delta Interaction Protein, p38, HSPC017, POLD4, PDIP38, POLDIP2) (PE)
MBS6472690-01 0.2 mL

DNA Polymerase delta Interacting Protein p38, CT (Polymerase delta-interacting Protein 2, 38kD DNA Polymerase delta Interaction Protein, p38, HSPC017, POLD4, PDIP38, POLDIP2) (PE)

Ask
View Details