Anti-BRMS1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Breast cancer metastasis-suppressor 1 is a protein that in humans is encoded by the BRMS1 gene. This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC) . The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.
Synonyms
Breast cancer metastasis-suppressor 1; BRMS1
Gene Name
BRMS1
Gene ID
25855
UniProt
Q9HCU9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human BRMS1 recombinant protein (Position: D52-D244) . Human BRMS1 shares 93.6% and 96% amino acid (aa) sequence identity with mouse and rat BRMS1, respectively.
Clonality
Polyclonal
Tissue Specificity
Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies. .
Applications
Flow Cytometry
Field of Research
Cancer Susceptibility, Epigenetics and Nuclear Signaling, Transcription, Tumor Suppressors
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. .
References & Citations
1. Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000) . Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. Cancer Res. 60 (11) : 2764–9. 2. Entrez Gene: BRMS1 breast cancer metastasis suppressor 1.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
28461 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Breast cancer metastasis-suppressor 1
Subcellular Location
Nucleus. Cytoplasm. Predominantly nuclear.
Protein Name
Breast cancer metastasis-suppressor 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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