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Anti-BRMS1 Antibody Picoband®

Boster Bio Anti-BRMS1 Antibody Picoband® catalog # A03587-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Breast cancer metastasis-suppressor 1 is a protein that in humans is encoded by the BRMS1 gene. This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC) . The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

Synonyms

Breast cancer metastasis-suppressor 1; BRMS1

Gene Name

BRMS1

Gene ID

25855

UniProt

Q9HCU9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human BRMS1 recombinant protein (Position: D52-D244) . Human BRMS1 shares 93.6% and 96% amino acid (aa) sequence identity with mouse and rat BRMS1, respectively.

Clonality

Polyclonal

Tissue Specificity

Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies. .

Applications

WB

Field of Research

Cancer Susceptibility, Epigenetics and Nuclear Signaling, Transcription, Tumor Suppressors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. .

References & Citations

1. Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000) . Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. Cancer Res. 60 (11) : 2764–9. 2. Entrez Gene: BRMS1 breast cancer metastasis suppressor 1.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

28461 MW

Observed Molecular Weight

34 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Breast cancer metastasis-suppressor 1

Subcellular Location

Nucleus. Cytoplasm. Predominantly nuclear.

Protein Name

Breast cancer metastasis-suppressor 1

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

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