Anti-TMEM107 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Cilia are dynamic signaling organelles essential for developmental patterning, including left-right specification, skeletal formation, neural development, and organogenesis. TMEM107 is predicted to be critical for cilia formation and signaling in a subset of embryonic tissues. Based on an alignment of theTMEM107 sequence with the genomic sequence (GRCh38), the TMEM107 gene was mapped to chromosome 17p13.1.
Synonyms
Transmembrane protein 107; TMEM107; DC20, UNQ638/PRO1268
Gene Name
TMEM107
Gene ID
84314
UniProt
Q6UX40
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human TMEM107, different from the related mouse and rat sequences by four amino acids.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous. .
Applications
Flow Cytometry
Field of Research
Cell Biology
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity) . .
References & Citations
1. Christopher, K. J., Wang, B., Kong, Y., Weatherbee, S. D. Forward genetics uncovers transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling. Dev. Biol. 368: 382-392, 2012. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 1/12/2015.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
15503 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Transmembrane protein 107
Subcellular Location
Membrane ; Multi-pass membrane protein .
Protein Name
Transmembrane protein 107
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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