Anti-IL-2/IL2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
IL-2, Interleukin-2, formerly referred to as T-cell growth factor, is a powerfully immunoregulatory lymphokine that is produced by lectin-or antigen-activated T cells. In situ hybridization, the IL-2 gene is assigned to 4q26-q28. IL2 can act as a growth hormone for both B and T lymphocytes. It is useful in the study of the molecular nature of T-cell differentiation and, like interferons, augments natural killer cell activity.
Synonyms
Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin; IL2
Gene Name
IL2
Gene ID
3558
UniProt
P60568
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human IL-2 recombinant protein (Position: A21-T153) . Human IL-2 shares 57.5% and 66.4% amino acid (aa) sequence identity with mouse and rat IL-2, respectively.
Clonality
Polyclonal
Tissue Specificity
Expressed in fetal brain.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, Cell Type Markers, Cytokines, Immunology, Innate Immunity, Interleukins, T Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells.
References & Citations
1. Lowenthal, J. W., Zubler, R. H., Nabholz, M., MacDonald, H. R.Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes.Nature 315: 669-672, 1985. 2. Seigel, L. J., Harper, M. E., Wong-Staal, F., Gallo, R. C., Nash, W. G., O'Brien, S. J.Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1.Science 223: 175-178, 1984. 3. Weinberg, K., Parkman, R.Severe combined immunodeficiency due to a specific defect in the production of interleukin-2.New Eng. J. Med. 322: 1718-1723, 1990.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
18 kDa
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Interleukin-2
Subcellular Location
Secreted.
Protein Name
Interleukin-2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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