Anti-HFE Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Human hemochromatosis protein also known as the HFE protein is a protein which in humans is encoded by the HFE gene. The HFE gene is located on short arm of chromosome 6 at location 6p21.3. The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M) . It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene.
Synonyms
Hereditary hemochromatosis protein; HLA-H; HFE; HLAH
Gene Name
HFE
Gene ID
3077
UniProt
Q30201
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human HFE recombinant protein (Position: Q82-R199) . Human HFE shares 72.2% and 74.6% amino acid (aa) sequence identity with mouse and rat HFE, respectively.
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues tested except brain.
Applications
Flow Cytometry
Field of Research
Cofactors, Vitamins/Minerals, Hematopoietic Progenitors, Metabolism, Myeloid, Pathways and Processes, Signal Transduction, Stem Cells, Vitamins/Minerals
Purification
Immunogen affinity purified.
Form
Liquid
Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. .
References & Citations
1. Martins, R; Silva, B; Proença, D; Faustino, P (3 March 2011) . Differential HFE gene expression is regulated by alternative splicing in human tissues. PLOS ONE. 6 (3) : e17542. 2. Waheed, A; Parkkila, S; Saarnio, J; Fleming, RE; Zhou, XY; Tomatsu, S; Britton, RS; Bacon, BR; Sly, WS (16 February 1999) . Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proceedings of the National Academy of Sciences of the United States of America. 96 (4) : 1579–84.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
40108 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Hereditary hemochromatosis protein
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Protein Name
Hereditary hemochromatosis protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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