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Anti-HFE Antibody Picoband®

Boster Bio Anti-HFE Antibody Picoband® catalog # A00506-1. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Human hemochromatosis protein also known as the HFE protein is a protein which in humans is encoded by the HFE gene. The HFE gene is located on short arm of chromosome 6 at location 6p21.3. The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M) . It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene.

Synonyms

Hereditary hemochromatosis protein; HLA-H; HFE; HLAH

Gene Name

HFE

Gene ID

3077

UniProt

Q30201

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human HFE recombinant protein (Position: Q82-R199) . Human HFE shares 72.2% and 74.6% amino acid (aa) sequence identity with mouse and rat HFE, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues tested except brain.

Applications

WB

Field of Research

Cofactors, Vitamins/Minerals, Hematopoietic Progenitors, Metabolism, Myeloid, Pathways and Processes, Signal Transduction, Stem Cells, Vitamins/Minerals

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. .

References & Citations

1. Martins, R; Silva, B; Proença, D; Faustino, P (3 March 2011) . Differential HFE gene expression is regulated by alternative splicing in human tissues. PLOS ONE. 6 (3) : e17542. 2. Waheed, A; Parkkila, S; Saarnio, J; Fleming, RE; Zhou, XY; Tomatsu, S; Britton, RS; Bacon, BR; Sly, WS (16 February 1999) . Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proceedings of the National Academy of Sciences of the United States of America. 96 (4) : 1579–84.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

40108 MW

Observed Molecular Weight

40 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Hereditary hemochromatosis protein

Subcellular Location

Cell membrane ; Single-pass type I membrane protein .

Protein Name

Hereditary hemochromatosis protein

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

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