Anti-RanBP1 Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene. This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP) . This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants.
Synonyms
Ran-specific GTPase-activating protein; Ran-binding protein 1; RanBP1; RANBP1
Gene Name
RANBP1
Gene ID
5902
UniProt
P43487
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human RanBP1 recombinant protein (Position: A2-Q201) . Human RanBP1 shares 93.1% amino acid (aa) sequence identity with mouse RanBP1.
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636) . Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636) . Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Applications
Flow Cytometry
Field of Research
Cell Biology, Cell Cycle, Cell Division, DNA/RNA, Epigenetics and Nuclear Signaling, Nuclear Import/Export, Protein Trafficking, RNA Processing, Signal Transduction, Spindle
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
References & Citations
1. Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T (August 1995) . RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. Mol Gen Genet. 247 (6) : 661–9. 2. Kehlenbach RH, Dickmanns A, Kehlenbach A, Guan T, Gerace L (July 1999) . A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export. J Cell Biol. 145 (4) : 645–57.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
23310 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Ran-specific GTPase-activating protein
Subcellular Location
Cytoskeleton. Nucleus. Cell cortex. Bleb.
Protein Name
Ran-specific GTPase-activating protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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