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Anti-RanBP1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene. This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP) . This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants.

Synonyms

Ran-specific GTPase-activating protein; Ran-binding protein 1; RanBP1; RANBP1

Gene Name

RANBP1

Gene ID

5902

UniProt

P43487

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RanBP1 recombinant protein (Position: A2-Q201) . Human RanBP1 shares 93.1% amino acid (aa) sequence identity with mouse RanBP1.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636) . Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636) . Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Division, DNA/RNA, Epigenetics and Nuclear Signaling, Nuclear Import/Export, Protein Trafficking, RNA Processing, Signal Transduction, Spindle

Purification

Immunogen affinity purified.

Form

Liquid

Function

Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.

References & Citations

1. Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T (August 1995) . RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. Mol Gen Genet. 247 (6) : 661–9. 2. Kehlenbach RH, Dickmanns A, Kehlenbach A, Guan T, Gerace L (July 1999) . A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export. J Cell Biol. 145 (4) : 645–57.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

23310 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Ran-specific GTPase-activating protein

Subcellular Location

Cytoskeleton. Nucleus. Cell cortex. Bleb.

Protein Name

Ran-specific GTPase-activating protein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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