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Anti-FDCSP Antibody Fluoro550 Conjugated

Product Specifications

Background

FDC-SP or follicular dendritic cell-secreted protein, is a small, secreted protein, located on chromosome 4 in humans. FDC-SP is a 68-amino acid protein containing a signal peptide at its N terminus, which is used for ing the transport of the protein. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion.

Synonyms

Follicular dendritic cell secreted peptide; FDC secreted protein; FDC-SP; FDCSP; C4orf7; UNQ733/PRO1419

Gene Name

FDCSP

Gene ID

260436

UniProt

Q8NFU4

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human FDCSP.

Clonality

Polyclonal

Tissue Specificity

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Applications

Flow Cytometry

Field of Research

Immunology, Secreted Molecules

Purification

Immunogen affinity purified.

Form

Liquid

Function

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

References & Citations

1. Aaron J. Marshall; et al. (September 1, 2002) . FDC-SP, a Novel Secreted Protein Expressed by Follicular Dendritic Cells. The Journal of Immunology. 169 (5) : 2381–2389. 2. Tamayuki Shinomura; et al. (November 28, 2008) . Adsorption of Follicular Dendritic Cell-secreted Protein (FDC-SP) onto Mineral Deposits. J. Biol. Chem. 283 (48) : 33658–33664.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

9700 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Follicular dendritic cell secreted peptide

Subcellular Location

Secreted.

Protein Name

Follicular dendritic cell secreted peptide

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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