Anti-ETS1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene. It is mapped to 11q24.3. This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis.
Synonyms
Protein C-ets-1; p54; ETS1; EWSR2
Gene Name
ETS1
Gene ID
2113
UniProt
P14921
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human ETS1, identical to the related mouse and rat sequences.
Clonality
Polyclonal
Tissue Specificity
Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. .
Applications
Flow Cytometry
Field of Research
Cancer, Cardiogenesis, Cardiovascular, Domain Families, Epigenetics and Nuclear Signaling, Oncoproteins, Oncoproteins/Suppressors, Transcription, Transcription Factors, Transcription Factors/Regulators
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcription factor. ly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. .
References & Citations
1. Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, de Jong P, Rouleau G (Sep 1992) . Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature. 359 (6391) : 162–5. 2. Dwyer J, Li H, Xu D, Liu JP (Oct 2007) . Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family. Annals of the New York Academy of Sciences. 1114 (1) : 36–47.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
50408 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Protein C-ets-1
Subcellular Location
Cytoplasm . Nucleus . Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. .
Protein Name
Protein C-ets-1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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