Anti-ECE1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene. The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Synonyms
Endothelin-converting enzyme 1; ECE-1;3.4.24.71; ECE1
Gene Name
ECE1
Gene ID
1889
UniProt
P42892
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ECE1 recombinant protein (Position: M18-T233) . Human ECE1 shares 94% and 93.5% amino acid (aa) sequence identity with mouse and rat ECE1, respectively.
Clonality
Polyclonal
Tissue Specificity
All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney. .
Applications
Flow Cytometry
Field of Research
Cancer, Cancer Metabolism, Cardiovascular, Growth Factors/Hormones, Metabolism, Metabolism Processes, Pathways and Processes, Response To Hypoxia, Signal Transduction, Vasculature
Purification
Immunogen affinity purified.
Form
Liquid
Function
Converts big endothelin-1 to endothelin-1. .
References & Citations
1. Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H (December 1994) . Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) . FEBS Lett. 356 (2–3) : 238–43. 2. Entrez Gene: ECE1 endothelin converting enzyme 1.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
87164 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Endothelin-converting enzyme 1
Subcellular Location
Cell membrane; Single-pass type II membrane protein.
Protein Name
Endothelin-converting enzyme 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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