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Anti-Dishevelled 2/DVL2 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A02404-3-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene. This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

Synonyms

Segment polarity protein dishevelled homolog DVL-2; Dishevelled-2; DSH homolog 2; DVL2

Gene Name

DVL2

Gene ID

1856

UniProt

O14641

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Dishevelled 2, identical to the related mouse sequence.

Clonality

Polyclonal

Tissue Specificity

Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

Applications

Flow Cytometry

Field of Research

Cytoplasmic, Signaling Pathways, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity) . .

References & Citations

1. Greco TL, Sussman DJ, Camper SA (January 1997) . Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11. Mamm Genome. 7 (6) : 475–6. 2. Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003) . Regulation of the Wnt signaling pathway by disabled-2 (Dab2) . EMBO J. England. 22 (12) : 3084–94.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

78948 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Segment polarity protein dishevelled homolog DVL-2

Subcellular Location

Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity) . .

Protein Name

Segment polarity protein dishevelled homolog DVL-2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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