Anti-CD166/ALCAM Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Synonyms
CD166 antigen; Activated leukocyte cell adhesion molecule; CD166; ALCAM; MEMD
Gene Name
ALCAM
Gene ID
214
UniProt
Q13740
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human CD166/ALCAM recombinant protein (Position: N167-E406) . Human CD166/ALCAM shares 90.8% amino acid (aa) sequence identity with both mouse and rat CD166/ALCAM.
Clonality
Polyclonal
Tissue Specificity
Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines. .
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, B Cells, Immunology, T Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.
References & Citations
1. Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U, et al. (Jun 1995) . Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J Exp Med. 181 (6) : 2213–20. 2. Fujiwara H, Tatsumi K, Kosaka K, et al. (2003) . Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166) ..J. Clin. Endocrinol. Metab.88 (7) : 3437–43.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
65102 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
CD166 antigen
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
CD166 antigen
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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