Anti-AKR1B10 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
Synonyms
Aldo-keto reductase family 1 member B10;1.1.1.-; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase; AKR1B10; AKR1B11
Gene Name
AKR1B10
Gene ID
57016
UniProt
O60218
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human AKR1B10.
Clonality
Polyclonal
Tissue Specificity
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
Applications
Flow Cytometry
Field of Research
Cancer, Drug Metabolism, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Tumor Biomarkers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro) . May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. .
References & Citations
1. Cao D, Fan ST, Chung SS (Jun 1998) . Identification and characterization of a novel human aldose reductase-like gene. J Biol Chem. 273 (19) : 11429–35. 2. Hyndman DJ, Flynn TG (Oct 1998) . Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family. Biochim Biophys Acta. 1399 (2–3) : 198–202.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
36020 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Aldo-keto reductase family 1 member B10
Subcellular Location
Lysosome . Secreted . Secreted through a lysosome-mediated non-classical pathway.
Protein Name
Aldo-keto reductase family 1 member B10
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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