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Anti-Periplakin/PPL Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Periplakin is a protein that in humans is encoded by the PPL gene. The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.

Synonyms

Periplakin;190 kDa paraneoplastic pemphigus antigen;195 kDa cornified envelope precursor protein; PPL; KIAA0568

Gene Name

PPL

Gene ID

5493

UniProt

O60437

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Periplakin, different from the related mouse sequence by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Expressed in stratified squamous epithelia and in some other epithelia. .

Applications

Flow Cytometry

Field of Research

Cancer, Cardiovascular, Fatty Acid Oxidation, Fatty Acids, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Redox Metabolism, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. .

References & Citations

1. Entrez Gene: PPL periplakin. 2. Aho S, McLean WH, Li K, Uitto J (Jun 1998) . cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes. Genomics. 48 (2) : 242–7. 3. Kazerounian, Shideh; Uitto Jouni; Aho Sirpa (Oct 2002) . Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin. Exp. Dermatol. Denmark. 11 (5) : 428–38.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

204747 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Periplakin

Subcellular Location

Cell junction, desmosome . Cytoplasm, cytoskeleton . Cell membrane . Nucleus . Mitochondrion . Associated with desmosomes and intermediate filaments.

Protein Name

Periplakin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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