Anti-NAT1 Antibody Picoband®

N-acetyltransferase 1 (arylamine N-acetyltransferase) is a protein that in humans is encoded by the NAT1 gene. This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.

Arylamine N-acetyltransferase 1;2.3.1.5; Arylamide acetylase 1; Monomorphic arylamine N-acetyltransferase; MNAT; N-acetyltransferase type 1; NAT-1; NAT1; AAC1

A synthetic peptide corresponding to a sequence at the C-terminus of human NAT1, different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

1. Entrez Gene: N-acetyltransferase 1 (arylamine N-acetyltransferase) . 2. De León, J. H.; Vatsis, K. P.; Weber, W. W. (2000) . Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1. Molecular Pharmacology. 58 (2) : 288–299. 3. Gubin, A. N.; Njoroge, J. M.; Bouffard, G. G.; Miller, J. L. (1999) . Gene Expression in Proliferating Human Erythroid Cells. Genomics. 59 (2) : 168–177.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.