Anti-MMP11 Antibody Picoband®

Stromelysin-3 (SL-3) also known as matrix metalloproteinase-11 (MMP-11) is an enzyme that in humans is encoded by the MMP11 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

A synthetic peptide corresponding to a sequence at the N-terminus of human MMP11, different from the related mouse and rat sequences by three amino acids.

Angiogenesis, Cancer, Cardiovascular, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

1. Entrez Gene: MMP11 matrix metallopeptidase 11 (stromelysin 3) . 2. Anglard P, Melot T, Guerin E, Thomas G, Basset P (Oct 1995) . Structure and promoter characterization of the human stromelysin-3 gene. J Biol Chem. 270 (35) : 20337–44. 3. Levy A, Zucman J, Delattre O, Mattei MG, Rio MC, Basset P (Aug 1992) . Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22. Genomics. 13 (3) : 881–3.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.