Anti-MC3 Receptor/MC3R Antibody Picoband®

Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene. It is mapped to 20q13.2. This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans.

A synthetic peptide corresponding to a sequence at the N-terminus of human MC3 Receptor, different from the related mouse sequence by six amino acids, and from the related rat sequence by seven amino acids.

Atherosclerosis, Cardiovascular, Fatty Acid Oxidation, Fatty Acids, Heart Disease, Lipid and Lipoprotein Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Neurology Process, Neuroscience, Pathways and Processes, Redox Metabolism, Vascular Inflammation

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. .

1. Entrez Gene: MC3R melanocortin 3 receptor. 2. Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T (Apr 1993) . Molecular cloning of a novel melanocortin receptor. The Journal of Biological Chemistry. 268 (11) : 8246–50. 3. Konda Y, Gantz I, DelValle J, Shimoto Y, Miwa H, Yamada T (May 1994) . Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor. The Journal of Biological Chemistry. 269 (18) : 13162–6.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.