What sizes are available for Anti-Cytokeratin 18/KRT18 Antibody Picoband® Fluoro647 Conjugated?

Anti-Cytokeratin 18/KRT18 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Anti-Cytokeratin 18/KRT18 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-Cytokeratin 18/KRT18 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-Cytokeratin 18/KRT18 Antibody Picoband® Fluoro647 Conjugated is A01357-1-Fluoro647.

Selected Variant

A01357-1-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Keratin 18, mapped to 12q13.13, is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

Synonyms

Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18; KRT18; CYK18; PIG46

Gene Name

KRT18

Gene ID

3875

UniProt

P05783

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human Cytokeratin 18 recombinant protein (Position: E204-H430) . Human Cytokeratin 18 shares 87.7% and 85.9% amino acid (aa) sequence identity with mouse and rat Cytokeratin 18, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. .

Applications

Flow Cytometry

Field of Research

Cell Type Markers, Class I, Cytoskeleton, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Intermediate Filaments, Microtubules, Signal Transduction, Structures, Tumor Associated

Purification

Immunogen affinity purified.

Form

Liquid

Function

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity) . When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6) -mediated barrier protection. .

References & Citations

1. Entrez Gene: KRT18 keratin 18. 2. Ku, N.-O., Wright, T. L., Terrault, N. A., Gish, R., Omary, M. B. Mutation of human keratin 18 in association with cryptogenic cirrhosis. J. Clin. Invest. 99: 19-23, 1997. 3. Ku, N.-O., Darling, J. M., Krams, S. M., Esquivel, C. O., Keeffe, E. B., Sibley, R. K., Lee, Y. M., Wright, T. L., Omary, M. B. Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies. Proc. Nat. Acad. Sci. 100: 6063-6068, 2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

48 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Keratin, type I cytoskeletal 18

Subcellular Location

Cytoplasm, perinuclear region. Nucleus, nucleolus.

Protein Name

Keratin, type I cytoskeletal 18

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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