Anti-Islet 1/ISL1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the isl1 gene. This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
Synonyms
Insulin gene enhancer protein ISL-1; Islet-1; ISL1
Gene Name
ISL1
Gene ID
3670
UniProt
P61371
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human Islet 1, identical to the related mouse and rat sequences.
Clonality
Polyclonal
Tissue Specificity
Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.
Applications
Flow Cytometry
Field of Research
Atherosclerosis, Cardiogenesis, Cardiovascular, Cell Type Marker, Developmental Biology, Diabetes-associated, Intracellular, Lineage Markers, Lineage Specification, Neural Stem Cells, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Organogenesis, Stem Cells, Transcription Factors/Regulators
Purification
Immunogen affinity purified.
Form
Liquid
Function
Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) . .
References & Citations
1. Entrez Gene: ISL1 ISL1 transcription factor, LIM/homeodomain, (islet-1) . 2. Gay F, Anglade I, Gong Z, Salbert G (October 2000) . The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. Mol. Endocrinol. 14 (10) : 1627–48. 3. Tanizawa Y, Riggs AC, Dagogo-Jack S, Vaxillaire M, Froguel P, Liu L, Donis-Keller H, Permutt MA (July 1994) . Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected]. Diabetes. 43 (7) : 935–41.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39036 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Insulin gene enhancer protein ISL-1
Subcellular Location
Nucleus.
Protein Name
Insulin gene enhancer protein ISL-1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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