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Anti-Nicotinic Acetylcholine Receptor alpha 5/CHRNA5 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

A02359-2-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Neuronal acetylcholine receptor subunit alpha-5 is a protein that in humans is encoded by the CHRNA5 gene. It is mapped to 15q25.1. The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2) .

Synonyms

Neuronal acetylcholine receptor subunit alpha-5; CHRNA5; NACHRA5

Gene Name

CHRNA5

Gene ID

1138

UniProt

P30532

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human CHRNA5, different from the related mouse sequence by five amino acids, and from the related rat sequence by four amino acids.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Receptors / Channels

Purification

Immunogen affinity purified.

Form

Liquid

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

References & Citations

1. Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5. 2. Chini, B., Clementi, F., Hukovic, N., Sher, E. Neuronal-type alpha-bungarotoxin receptors and the alpha-5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines. Hum. Genet. 89: 1572-1576, 1992. 3. Wang, J. C., Cruchaga, C., Saccone, N. L., Bertelsen, S., Liu, P., Budde, J. P., Duan, W., Fox, L., Grucza, R. A., Kern, J., Mayo, K., Reyes, O., and 12 others. Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Hum. Molec. Genet. 18: 3125-3135, 2009.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

53054 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Neuronal acetylcholine receptor subunit alpha-5

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Protein Name

Neuronal acetylcholine receptor subunit alpha-5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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