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Anti-Superoxide Dismutase 4/CCS Antibody Picoband®

Boster Bio Anti-Superoxide Dismutase 4/CCS Antibody Picoband® catalog # A00314-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Copper chaperone for superoxide dismutase is a metalloprotein that is responsible for the delivery of Cu to superoxide dismutase (SOD1) . In humans the protein is encoded by the CCS gene. And this gene is mapped to chromosome 11q13 by fluorescence in situ hybridization. The CCS protein is present in mammals and most eukaryotes including yeast. The structure of CCS is composed of three distinct domains that are necessary for its function. Although CCS is important for many organisms, there are CCS independent pathways for SOD1, and many species lack CCS all together, such as C. elegans.

Synonyms

Copper chaperone for superoxide dismutase; Superoxide dismutase copper chaperone; CCS

Gene Name

CCS

Gene ID

9973

UniProt

O14618

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human CCS, different from the related mouse sequence by six amino acids, and from the related rat sequence by seven amino acids.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

IHC, WB

Field of Research

Cancer, Cardiovascular, Metabolism, Neuroscience, Neurotransmission, Plasma Membrane, Potassium Channels, Receptors / Channels, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Delivers copper to copper zinc superoxide dismutase (SOD1) .

References & Citations

1. Bartnikas, T. B., Waggoner, D. J., Casareno, R. L. B., Gaedigk, R., White, R. A., Gitlin, J. D. Chromosomal localization of CCS, the copper chaperone for Cu/Zn superoxide dismutase. Mammalian Genome 11: 409-411, 2000. 2. Casareno, R. L. B., Waggoner, D., Gitlin, J. D. The copper chaperone CCS ly interacts with copper/zinc superoxide dismutase.J. Biol. Chem. 273: 23625-23628, 1998. 3. Huppke, P., Brendel, C., Korenke, G. C., Marquardt, I., Donsante, A., Yi, L., Hicks, J. D., Steinbach, P. J., Wilson, C., Elpeleg, O., Moller, L. B., Christodoulou, J., Kaler, S. G., Gartner, J. Molecular and biochemical characterization of a unique mutation in CCS, the human copper chaperone to superoxide dismutase. Hum. Mutat. 33: 1207-1215, 2012.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

29041 MW

Observed Molecular Weight

34 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Copper chaperone for superoxide dismutase

Subcellular Location

Cytoplasm .

Protein Name

Copper chaperone for superoxide dismutase

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

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