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Anti-Hydrogen Potassium ATPase Beta/ATP4B Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

This gene encodes the beta subunit of the gastric H+, K+-ATPase. The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H (+) and K (+) ions across the plasma membrane. It is also responsible for gastric acid secretion.

Synonyms

Potassium-transporting ATPase subunit beta; Gastric H (+) /K (+) ATPase subunit beta; Proton pump beta chain; ATP4B

Gene Name

ATP4B

Gene ID

496

UniProt

P51164

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human ATP4B, different from the related mouse and rat sequences by five amino acids.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

ATPases, Cancer, Cofactors, Vitamins/Minerals, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction, Vitamins/Minerals

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. .

References & Citations

1. Canfield, V. A., Okamoto, C. T., Chow, D., Dorfman, J., Gros, P., Forte, J. G., Levenson, R. Cloning of the H, K-ATPase beta subunit: tissue-specific expression, chromosomal assignment, and relationship to Na, K-ATPase beta subunits. J. Biol. Chem. 265: 19878-19884, 1990. 2. Reuben, M. A., Lasater, L. S., Sachs, G. Characterization of a beta subunit of the gastric H (+) /K (+) -transporting ATPase. Proc. Nat. Acad. Sci. 87: 6767-6771, 1990. 3. Song, I., Brown, D. R., Yamada, T., Trent, J. M. Mapping of the gene encoding the beta-subunit of H (+), K (+) -ATPase to human chromosome 13q34 by fluorescence in situ hybridization. Genomics 14: 1114-1115, 1992.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

33367 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Potassium-transporting ATPase subunit beta

Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Protein Name

Potassium-transporting ATPase subunit beta

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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