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Anti-Annexin VIII/ANXA8 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A08645-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

ANXA8 is also known as ANNEXIN VIII. This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that inly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.

Synonyms

Annexin A8 ; Annexin VIII ; Annexin-8 ; Vascular anticoagulant-beta ; VAC-beta ; ANXA8 ; ANX8

Gene Name

ANXA8

Gene ID

653145

UniProt

P13928

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Annexin VIII, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed.

Applications

Flow Cytometry

Field of Research

Signal Transduction, Cardiovascular, Cytoskeleton, Cytoskeleton/ECM, Actin Binding Proteins, Actin, etc., Microfilaments, Cell Adhesion

Purification

Immunogen affinity purified.

Form

Liquid

Function

This protein is an anticoagulant protein that acts as an in inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

References & Citations

1. Chambers, J. A., Gardner, E., Hauptmann, R., Ponder, B. A., Mulligan, L. M. TaqI polymorphisms at the annexin VIII locus (ANX8) . Hum. Molec. Genet. 1: 550 only, 1992. 2. Chang, K.-S., Wang, G., Freireich, E. J., Daly, M., Naylor, S. L., Trujillo, J. M., Stass, S. A. Specific expression of the annexin VIIIgene in acute promyelocytic leukemia. Blood 79: 1802-1810, 1992. 3. Sarkar, A., Yang, P., Fan, Y.-H., Mu, Z. M., Hauptmann, R., Adolf, G. R., Stass, S. A., Chang, K.-S. Regulation of the expression ofannexin VIII in acute promyelocytic leukemia. Blood 84: 279-286, 1994.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

36881 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Annexin A8

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Protein Name

Annexin A8

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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