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Anti-AKAP2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

A-kinase anchor protein 2 is an enzyme that in humans is encoded by the AKAP2 gene. It is mapped to 9q31.3. The protein encoded by this gene binds to the regulatory subunit of protein kinase A and is found associated with the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found for this gene.

Synonyms

A-kinase anchor protein 2; AKAP-2; AKAP-KL; Protein kinase A-anchoring protein 2; PRKA2; AKAP2; KIAA0920, PRKA2

Gene Name

AKAP2

Gene ID

11217

UniProt

Q9Y2D5

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human AKAP2, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.

Applications

Flow Cytometry

Field of Research

Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity) . .

References & Citations

1. Entrez Gene: AKAP2 A kinase (PRKA) anchor protein 2. 2. Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003) . Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc. Natl. Acad. Sci. U.S.A. 100 (8) : 4445–50. 3. Dong F, Feldmesser M, Casadevall A, Rubin CS (Mar 1998) . Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein. J. Biol. Chem. 273 (11) : 6533–41.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

94661 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

A-kinase anchor protein 2

Subcellular Location

Secreted .

Protein Name

A-kinase anchor protein 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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