Anti-DR4/TNFRSF10A Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
TNFRSF10A (Tumor Necrosis Factor Receptor Subfamily Member 10A), also known as APO2, DR4 or TRAILR1, is a protein that in humans is encoded by the TNFRSF10A gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Synonyms
Tumor necrosis factor receptor superfamily member 10A; Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD261; TNFRSF10A; APO2, DR4, TRAILR1
Gene Name
TNFRSF10A
Gene ID
8797
UniProt
O00220
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human DR4.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
Applications
Flow Cytometry
Field of Research
Apoptosis, Cell Biology, Cytokines, Immunology, Innate Immunity, Receptors, TNF Superfamily
Purification
Immunogen affinity purified.
Form
Liquid
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. .
References & Citations
1. Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997) . TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16 (17) : 5386–97. 2. Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997) . The receptor for the cytotoxic ligand TRAIL. Science. 276 (5309) : 111–3.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
50089 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Tumor necrosis factor receptor superfamily member 10A
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
Tumor necrosis factor receptor superfamily member 10A
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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