Anti-ATTY/TAT Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked.
Synonyms
Tyrosine aminotransferase; TAT;2.6.1.5; L-tyrosine:2-oxoglutarate aminotransferase; TAT
Gene Name
TAT
Gene ID
6898
UniProt
P17735
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human ATTY, different from the related mouse and rat sequences by two amino acids.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Antiviral Signaling,2339, Epigenetics and Nuclear Signaling, Immune System Diseases, Immunology, Microbiology
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro) . Has much lower affinity and transaminase activity towards phenylalanine. .
References & Citations
1. Natt E, Kida K, Odievre M, Di Rocco M, Scherer G (October 1992) . Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II. Proc. Natl. Acad. Sci. U.S.A. 89 (19) : 9297–301. 2. Rettenmeier R, Natt E, Zentgraf H, Scherer G (July 1990) . Isolation and characterization of the human tyrosine aminotransferase gene. Nucleic Acids Res. 18 (13) : 3853–61.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
50399 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Tyrosine aminotransferase
Subcellular Location
Cell membrane.
Protein Name
Tyrosine aminotransferase
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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