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Anti-TACC1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Transforming acidic coiled-coil-containing protein 1?is a?protein?that in humans is encoded by the?TACC1?gene. This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene.

Synonyms

Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1; TACC1; KIAA1103

Gene Name

TACC1

Gene ID

6867

UniProt

O75410

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human TACC1, different from the related mouse sequence by fourteen amino acids.

Clonality

Polyclonal

Tissue Specificity

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. .

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Differentiation, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

References & Citations

1. Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D (Jun 2004) . Aurora B -TACC1 protein complex in cytokinesis.Oncogene. 23 (26) : 4516–22. 2. Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003) . TACC1-chTOG-Aurora A protein complex in breast cancer. Oncogene. 22 (50) : 8102–16.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

87794 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Transforming acidic coiled-coil-containing protein 1

Subcellular Location

Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. .

Protein Name

Transforming acidic coiled-coil-containing protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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