Anti-Vesicular Acetylcholine Transporter/SLC18A3 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
The Vesicular acetylcholine transporter (VAChT), also known as SLC18A3, is a neurotransmitter transporter which is responsible for loadingacetylcholine (ACh) into secretory organelles in neurons making acetylcholine available for secretion. It is encoded by Solute carrier family 18, member 3 (SLC18A3) gene. This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene.
Synonyms
Vesicular acetylcholine transporter; VAChT; Solute carrier family 18 member 3; SLC18A3; VACHT
Gene Name
SLC18A3
Gene ID
6572
UniProt
Q16572
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human SLC18A3, different from the related mouse and rat sequences by five amino acids.
Clonality
Polyclonal
Tissue Specificity
Peripheral and central cholinergic nervous systems. .
Applications
Flow Cytometry
Field of Research
Neuroscience, Neurotransmitter
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in acetylcholine transport into synaptic vesicles. .
References & Citations
1. Erickson JD, Varoqui H (Dec 2000) . Molecular analysis of vesicular amine transporter function and targeting to secretory organelles. FASEB Journal. 14 (15) : 2450–8. 2. Weihe E, Tao-Cheng JH, Schäfer MK, Erickson JD, Eiden LE (Apr 1996) . Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles. Proceedings of the National Academy of Sciences of the United States of America. 93 (8) : 3547–52.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
56903 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Vesicular acetylcholine transporter
Subcellular Location
Membrane ; Multi-pass membrane protein .
Protein Name
Vesicular acetylcholine transporter
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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