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Anti-GAB1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene. It is mapped to 4q31.21. The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1; GAB1

Gene Name

GAB1

Gene ID

2549

UniProt

Q13480

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human GAB1, different from the related mouse sequence by one amino acid.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Adapters, Apoptosis, Cancer, Cell Biology, Cell Cycle, Cell Differentiation, Cytoplasmic, Intracellular, Kinases, MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) .

References & Citations

1. Entrez Gene: GAB1 GRB2-associated binding protein 1. 2. Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ (April 1996) . A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature. 379 (6565) : 560–4. 3. Rocchi S, Tartare-Deckert S, Murdaca J, Holgado-Madruga M, Wong AJ, Van Obberghen E (July 1998) . Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules. Mol. Endocrinol. 12 (7) : 914–23.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

76616 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

GRB2-associated-binding protein 1

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Protein Name

GRB2-associated-binding protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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