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Anti-CNPase Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

2',3'-Cyclic-nucleotide 3'-phosphodiesterase, also known as CNPase, is an enzyme that in humans is encoded by the CNP gene. And this gene is mapped to 17q21.2. CNPase is named for its ability to catalyze the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. CNPase is thought to play a critical role in the events leading up to myelination. Additionally, CNPase has been demonstrated to inhibit the replication of HIV-1 and other primate lentiviruses by binding the retroviral Gag protein and inhibiting the genesis of nascent viral particles.

Synonyms

2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNP; CNPase;3.1.4.37; CNP

Gene Name

CNP

Gene ID

1267

UniProt

P09543

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human CNPase, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Cell Type Marker, Cell Type Markers, Neurodegenerative Disease, Neurology Process, Neuroscience, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. .

References & Citations

1. Entrez Gene: CNP 2',3'-cyclic nucleotide 3' phosphodiesterase. 2. Hinman JD, Chen CD, Oh SY, Hollander W, Abraham CR (Jan 2008) . Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts. Glia. 56 (1) : 118–33. 3. Sprinkle TJ, Lanclos KD, Lapp DF (Jul 1992) . Assignment of the human 2',3'-cyclic nucleotide 3'-phosphohydrolase gene to chromosome 17.Genomics. 13 (3) : 877–80.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

47579 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Subcellular Location

Membrane; Lipid-anchor. Melanosome. Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Protein Name

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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