Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Placental alkaline phosphatase (PLAP) /ALPP Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A01718-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene. The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells.

Synonyms

Alkaline phosphatase, placental type;3.1.3.1; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1; ALPP; PLAP

Gene Name

ALPP

Gene ID

250

UniProt

P05187

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human ALPP.

Clonality

Polyclonal

Tissue Specificity

Detected in placenta (at protein level) . .

Applications

Flow Cytometry

Field of Research

Cancer, Tags & Cell Markers, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460) . Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114) . .

References & Citations

1. Entrez Gene: ALPP alkaline phosphatase, placental (Regan isozyme) . 2. Henthorn PS, Knoll BJ, Raducha M, Rothblum KN, Slaughter C, Weiss M, Lafferty MA, Fischer T, Harris H (Sep 1986) . Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids. Proc Natl Acad Sci U S A. 83 (15) : 5597–601. 3. Kam W, Clauser E, Kim YS, Kan YW, Rutter WJ (Feb 1986) . Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA. Proc Natl Acad Sci U S A. 82 (24) : 8715–9.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

57954 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Alkaline phosphatase, placental type

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Name

Alkaline phosphatase, placental type

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

Sign In for Pricing

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Progesterone (6-5E-10B), Biotin conjugate, 0.1mg/mL
BNCB0237-100 1x 100 µL

Progesterone (6-5E-10B), Biotin conjugate, 0.1mg/mL

Sign In for Pricing
View Details
6X His tag Mouse Monoclonal Antibody [A5D1]
HA600030 100 µL

6X His tag Mouse Monoclonal Antibody [A5D1]

Sign In for Pricing
View Details
WT1 (Wilm's Tumor 1) (6F-H2), 0.2mg/mL
BNUB0856-500 1x 500 µL

WT1 (Wilm's Tumor 1) (6F-H2), 0.2mg/mL

Sign In for Pricing
View Details
Anti-GRK5 Antibody Picoband® (Carrier-free Conjugate)
PB9708-carrier-free 100 µg/Vial

Anti-GRK5 Antibody Picoband® (Carrier-free Conjugate)

Sign In for Pricing
View Details
Catenin, gamma (Cardiomyocyte Marker) (CTNG/2155R), CF740 conjugate, 0.1mg/mL
BNC742155-500 1x 500 µL

Catenin, gamma (Cardiomyocyte Marker) (CTNG/2155R), CF740 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Desmin (Muscle Cell Marker) (D33), 0.2mg/mL
BNUB1722-100 1x 100 µL

Desmin (Muscle Cell Marker) (D33), 0.2mg/mL

Sign In for Pricing
View Details