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Anti-Placental alkaline phosphatase (PLAP) /ALPP Antibody Picoband®

Selected Variant

A01718

Size: 100 µg/Vial

Boster Bio Anti-Placental alkaline phosphatase (PLAP) /ALPP Antibody Picoband® catalog # A01718. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene. The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells.

Synonyms

Alkaline phosphatase, placental type;3.1.3.1; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1; ALPP; PLAP

Gene Name

ALPP

Gene ID

250

UniProt

P05187

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human ALPP.

Clonality

Polyclonal

Tissue Specificity

Detected in placenta (at protein level) . .

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Cancer, Tags & Cell Markers, Tumor Biomarkers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460) . Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114) . .

References & Citations

1. Entrez Gene: ALPP alkaline phosphatase, placental (Regan isozyme) . 2. Henthorn PS, Knoll BJ, Raducha M, Rothblum KN, Slaughter C, Weiss M, Lafferty MA, Fischer T, Harris H (Sep 1986) . Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids. Proc Natl Acad Sci U S A. 83 (15) : 5597–601. 3. Kam W, Clauser E, Kim YS, Kan YW, Rutter WJ (Feb 1986) . Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA. Proc Natl Acad Sci U S A. 82 (24) : 8715–9.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

57954 MW

Observed Molecular Weight

70 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Alkaline phosphatase, placental type

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Name

Alkaline phosphatase, placental type

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Price

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